Impact of Age and Immune System Function on Recurrent Tonsillitis: A Systematic Review of Qualitative Studies

Authors

  • Jamilu Garba Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Sokoto State, Nigeria.
  • Abdullahi Mohammed Sheikh Department of Anatomy, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Sokoto State, Nigeria.
  • Tiamiyu Abdulbashir Ayinde Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Agriculture P M B 28 Zuru Kebbi State Nigeria.
  • Barka John Department of Human Nutrition and Dietetics, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Sokoto State, Nigeria.
  • Ogagaoghene Abada Department of Agricultural Technology, Federal Polytechnic Monguno, Monguno, P.M.B. 1046, Borno State, Nigeria.
  • Ismaila Akeem Adesola Department of Agricultural Education, School of Vocational and Technical Education, Sa’adatu Rimi College of Education, P.M.B. 1014, Kano State, Nigeria.
  • Maina Babagana Bukar Department of Agricultural Education, School of Vocational and Technical Education, Sa’adatu Rimi College of Education, P.M.B. 1014, Kano State, Nigeria.
  • Sulaiman Ya’u Muhammad Hasfat Model Academy, Back Mobil Filling Station, Gesse Phase 3, Birnin Kebbi, Kebbi State, Nigeria.
  • Hadiza Isah Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria.
  • Kwata Veronical John Primary Health Care Department, Kala Balge Local Government Area, Borno State, Nigeria.
  • Sadiya Mohammed Umar Department of Pharmacology and Therapeutics, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Sokoto State, Nigeria.
  • Abolaji Olaitan Kabir Department of Biology, Adamu Augie College of Education, P.M.B. 1019, Argungu, Kebbi State, Nigeria.
  • Usman Shehu Yakubu Department of Veterinary Pathology, Faculty of Veterinary Medicine, Federal University of Agriculture, P.M.B. 2271, Zuru, Kebbi State, Nigeria.
  • Sanusi Muhammad Mairiga Department of Agricultural Technology, Federal Polytechnic Monguno, Monguno PMB 1066, Borno State, Nigeria.

DOI:

https://doi.org/10.54987/jobimb.v13i2.1174

Keywords:

Adult, Children, Immune system, Recurrent tonsillitis, Systematic review

Abstract

Recurrent tonsillitis is a highly incapacitating illness that impacts millions of people throughout the globe. The study "Unveiling the Impact of Age and Immune System on Recurrent Tonsillitis" offers significant findings on the correlation between age, immune system, and recurrent tonsillitis. Through a database search, we found a total of 189 records. Out of these, 127 records were deemed suitable for the investigations. However, only 62 records were actually examined due to duplication or lack of relevance. After conducting a more thorough analysis, we determined that 54 entries should be removed. Out of them, 24 were deemed irrelevant and 27 were identified as duplicates. In addition, three records were eliminated for alternative reasons. After evaluating 66 complete articles to determine their suitability, we incorporated 20 studies into a qualitative analysis and 20 studies into a quantitative analysis without meta-analysis because the studies lacked significant similarity. This systematic review was conducted in accordance with the reporting criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The results of our study demonstrate a notable association between age and impaired immune system performance in individuals with recurrent tonsillitis. The risk of bias assessment revealed methodological issues in current studies, underscoring the necessity for rigorous research. Our thorough investigation offers a structure for comprehending the intricate relationship between age, the immune system, and recurring tonsillitis. This study serves as a clarion call for future studies to overcome the methodological inadequacies and understand the riddles behind this ailment, opening the way for innovative treatments.

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Published

12.12.2025

How to Cite

Garba, J., Sheikh, A. M. ., Ayinde, T. A. ., John, B., Abada, O., Adesola, I. A. ., Bukar, M. B., Muhammad, S. Y., Isah, H., John, K. V., Umar, S. M., Kabir, A. O., Yakubu , U. S., & Mairiga , S. M. (2025). Impact of Age and Immune System Function on Recurrent Tonsillitis: A Systematic Review of Qualitative Studies. Journal of Biochemistry, Microbiology and Biotechnology, 13(2), 198–214. https://doi.org/10.54987/jobimb.v13i2.1174

Issue

Vol. 13 No. 2 (2025)

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Articles

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Copyright (c) 2025 Jamilu Garba, Abdullahi Mohammed Sheikh, Tiamiyu Abdulbashir Ayinde, Barka John, Ogagaoghene Abada, Ismaila Akeem Adesola, Maina Babagana Bukar, Sulaiman Ya’u Muhammad, Hadiza Isah, Kwata Veronical John, Sadiya Mohammed Umar, Abolaji Olaitan Kabir, Usman Shehu Yakubu , Sanusi Muhammad Mairiga

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