Weight Gain and Adipose Tissue Accumulation in Diabetic and Prediabetic Rats Fed with Palm Olein enriched High Fat Diet

Authors

  • Xuan-Yi Sim USM-RIKEN International Centre of Aging Science, USM, 11800 Minden, Penang, Malaysia.
  • Waqas Ahmad School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
  • Yan-Fen Lee School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
  • Ying-Hui Teh School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
  • Vikneswaran Murugaiyah School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
  • Baharudin Ibrahim School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
  • Peter Greimel RIKEN Centre for Brain Sciences, Laboratory for Cell Function Dynamics, Wako, Saitama 351-0198, Japan.
  • Lay-Harn Gam School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

DOI:

https://doi.org/10.54987/jobimb.v8i1.500

Keywords:

adipose tissue, diabetic, prediabetic, high fat diet

Abstract

Diabetic is known to be the main non-commutable public health concern.  In this study, we evaluated the relationship between diet, body weight and accumulation of adipose tissue in healthy, diabetic and prediabetic rats.  Physiologically, adipose tissue plays a central role in lipid and glucose metabolisms. Therefore, accumulation of adipose tissue in diabetic and prediabetic may lead to others non-commutable diseases.  The rats in control, diabetic and prediabetic groups were fed with normal and high fat diets for 6 consecutive weeks, while the rats in 4 sub-groups of diabetic and prediabetic groups also received metformin, a common drug to control diabetes.  The results indicated that in diabetic rats, a small increase of food calories by high fat diet caused a significant gained in body weight and a significant increase in adipose tissue accumulation with or without metformin treatment, however in prediabetic rats, rats with metformin treatment shown to be beneficial in maintaining body weight and adipose accumulation.  The data of the study imply that balance diet at high calories should be practiced by patients as high fat diet with similar calories can caused a significant health deterioration to the patients in term of body weight gained and adipose tissue accumulation.

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Published

31.07.2020

How to Cite

Sim, X.-Y., Ahmad, W., Lee, Y.-F., Teh, Y.-H., Murugaiyah, V., Ibrahim, B., Greimel, P., & Gam, L.-H. (2020). Weight Gain and Adipose Tissue Accumulation in Diabetic and Prediabetic Rats Fed with Palm Olein enriched High Fat Diet. Journal of Biochemistry, Microbiology and Biotechnology, 8(1), 1–6. https://doi.org/10.54987/jobimb.v8i1.500

Issue

Vol. 8 No. 1 (2020)

Section

Articles

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