Emerging Soluble Protein Markers in Colorectal Cancer

Authors

  • Nor Adzimah Johdi UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
  • Rahman Jamal UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.

DOI:

https://doi.org/10.54987/jobimb.v6i2.429

Keywords:

Cytokines, chemokines, colorectal carcinoma, interleukins, expression

Abstract

Small soluble proteins that are part of immune regulation such as cytokines, chemokines and growth factors are significantly involved in the pathogenesis of cancers. Their increase concentration in biological fluids and tissues suggest pathway activation that involves in inflammatory response or cancer progression. The knowledge of these soluble proteins has increasing clinical importance as a biomarker tool in screening, diagnosis classification, therapeutic surveillance and intervention. The review gives a short insight into the most commonly reported cytokines, chemokines and growth factors and their potential roles in the carcinogenesis. We discuss recent findings on their functions in colorectal carcinoma through analysis of their expression patterns, the use of selective inhibitors and signaling pathways involved.

Downloads

Published

31.12.2018

How to Cite

Johdi, N. A., & Jamal, R. (2018). Emerging Soluble Protein Markers in Colorectal Cancer. Journal of Biochemistry, Microbiology and Biotechnology, 6(2), 19–23. https://doi.org/10.54987/jobimb.v6i2.429

Issue

Vol. 6 No. 2 (2018)

Section

Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).