Catalytically active nanomaterials: A promising candidate for artificial enzymes
AbstractEnzymes are highly efficient biomolecules that speed up biochemical reactions. They usually exhibit high specificity to their distinctive substrates with enzymatic activities normally taking place in mild conditions . Enzymes provide significant number of assistance from mediating cellular metabolisms to the utilization in industrial processes such as pharmaceutical, food and agrochemical industries. However, ‘natural limitations’ hinder the usage of enzymes to its maximum trajectory e.g. harsh environmental condition that affects catalytic capability (i.e. by protein denaturation or enzyme being digested). In addition, there are many difficulties that affect enzyme recovery and industrial operation often requires exorbitant cost of preparation for purification . While the advancement in biotechnology leads to the exploration of biomolecules with enzymatic properties including cyclodextrins, metal complexes, porphyrins, polymers, and dendrimers, nanobiotechnology explores nanomaterials. There are varieties of nanomaterials that have been extensively explored to mimic the structures and functions of naturally occurring enzymes, namely; gold nanoparticles, platinum nanomaterials, nanoceria, iron and copper oxides, manganese dioxide and others. These nanomaterials (with artificial enzyme mimicking activities) were successfully utilized in immunoassays, cancer diagnostics and therapies, neuroprotection, stem cell growth, pollutant removal and biosensing applications .
Copyright (c) 2014 Nanobio and BioNano
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).