Exposure and Toxicity of Polybrominated Diphenyl Ethers: A Mini Review
DOI:
https://doi.org/10.54987/jemat.v11i2.846Keywords:
Polybrominated Flame Retardant, Uses, Toxic effects, Monitoring, ExposureAbstract
Polybrominated Diphenyl Ethers (PBDEs), recognized as persistent organic pollutants by the United Nations Environment Programme, are a class of brominated flame retardants that pose significant environmental and health risks. These compounds, consisting of two aromatic rings with up to 10 bromine atom substitutions, are categorized into penta-BDE, octa-BDE, and deca-BDE based on their bromine content, each exhibiting distinct environmental behaviors. PBDEs with fewer bromine atoms are more volatile and prone to bioaccumulation, raising significant health concerns. These compounds, often added physically to products, can leach into the environment, leading to pollution during production and after the parent polymer degrades. The transformation of higher brominated diphenyl ethers into less brominated forms in the environment further complicates their impact, with mono-brominated BDE-3 being particularly concerning due to its extended atmospheric photolysis lifetime and increased bioavailability. The management of PBDEs is challenging due to their persistence and transformation in the environment. As endocrine disruptors, they are linked to various acute and chronic toxicological effects, including neurodevelopmental toxicity, teratogenicity, and potential carcinogenicity. Their structural similarity to thyroid hormones allows them to disrupt thyroid hormone balance, leading to further health complications. The subject of this review is to summarize the current body of knowledge that is essential to understand their long-term effects on ecosystems and human health and to develop strategies to mitigate their adverse impacts.
References
Ballschmiter K, Zell M. Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography: Composition of technical aroclor- and Clophen-PCB mixtures. Fresenius Z Für Anal Chem. 1980 Jan;302(1):20-31.
U.S. Environmental Protection Agency. An exposure assessment of polybrominated diphenyl ethers. 2010.
Shaw SD, Blum A, Weber R, Kannan K, Rich D, Lucas D, et al. Halogenated flame retardants: do the fire safety benefits justify the risks? Rev Environ Health. 2010;25(4):261-305.
Hull TR, Law RJ, Bergman Å. Environmental Drivers for Replacement of Halogenated Flame Retardants. In: Polymer Green Flame Retardants [Internet]. Elsevier; 2014 [cited 2023 Dec 29]. p. 119-79. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780444538086000044
Sharkey M, Harrad S, Abou-Elwafa Abdallah M, Drage DS, Berresheim H. Phasing-out of legacy brominated flame retardants: The UNEP Stockholm Convention and other legislative action worldwide. Environ Int. 2020 Nov;144:106041.
Gill S, Hou Y, Li N, Pulido O, Bowers W. Developmental neurotoxicity of polybrominated diphenyl ethers mixture de71 in Sprague-Dawley rats. J Toxicol Environ Health A. 2016;79(12):482-93.
Yogui GT, Sericano JL. Polybrominated diphenyl ether flame retardants in the U.S. marine environment: A review. Environ Int. 2009 Apr;35(3):655-66.
Raff JD, Hites RA. Deposition versus Photochemical Removal of PBDEs from Lake Superior Air. Environ Sci Technol. 2007 Oct 1;41(19):6725-31.
Li X, Huang J, Fang L, Yu G, Lin H, Wang L. Photodegradation of 2,2?,4,4?-tetrabromodiphenyl ether in nonionic surfactant solutions. Chemosphere. 2008 Nov;73(10):1594-601.
Zhuang Y, Ahn S, Luthy RG. Debromination of Polybrominated Diphenyl Ethers by Nanoscale Zerovalent Iron: Pathways, Kinetics, and Reactivity. Environ Sci Technol. 2010 Nov 1;44(21):8236-42.
Zhuang Y, Jin L, Luthy RG. Kinetics and pathways for the debromination of polybrominated diphenyl ethers by bimetallic and nanoscale zerovalent iron: Effects of particle properties and catalyst. Chemosphere. 2012 Oct;89(4):426-32.
Huang K, Lu G, Lian W, Xu Y, Wang R, Tang T, et al. Photodegradation of 4,4?-dibrominated diphenyl ether in Triton X-100 micellar solution. Chemosphere. 2017 Aug;180:423-9.
Sutha J, Anila PA, Umamaheswari S, Ramesh M, Narayanasamy A, Poopal RK, et al. Biochemical responses of a freshwater fish Cirrhinus mrigala exposed to tris(2-chloroethyl) phosphate (TCEP). Environ Sci Pollut Res. 2020 Sep;27(27):34369-87.
Zhang M, Zhao F, Zhang J, Shi J, Tao H, Ge H, et al. Toxicity and accumulation of 6-OH-BDE-47 and newly synthesized 6,6?-diOH-BDE-47 in early life-stages of Zebrafish (Danio rerio). Sci Total Environ. 2021 Apr;763:143036.
Ding G, Yu J, Cui C, Chen L, Gao Y, Wang C, et al. Association between prenatal exposure to polybrominated diphenyl ethers and young children's neurodevelopment in China. Environ Res. 2015 Oct;142:104-11.
Poston RG, Saha RN. Epigenetic Effects of Polybrominated Diphenyl Ethers on Human Health. Int J Environ Res Public Health. 2019 Jul 29;16(15):2703.
Siddiqi MA, Laessig RH, Reed KD. Polybrominated diphenyl ethers (PBDEs): new pollutants-old diseases. Clin Med Res. 2003 Oct;1(4):281-90.
You X, Xi J, Cao Y, Zhang J, Luan Y. 4-Bromodiphenyl Ether Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans. Toxicol Sci. 2017 Jun;157(2):510-8.
Yu L, Han Z, Liu C. A review on the effects of PBDEs on thyroid and reproduction systems in fish. Gen Comp Endocrinol. 2015 Aug;219:64-73.
Yu L, Liu C, Chen Q, Zhou B. Endocrine disruption and reproduction impairment in zebrafish after long?term exposure to DE?71. Environ Toxicol Chem. 2014 Jun;33(6):1354-62.
Alaee M. An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. Environ Int. 2003 Sep;29(6):683-9.
Grand View Research. Flame Retardant Market Size, Share & Trends Analysis Report By Product (Halogenated, Non-halogenated), By Application, By End Use, By Region, And Segment Forecasts. 2020.
ATSDR (Agency for Toxic Substance and Disease Registry). Toxicological profile for polybrominated biphenyl and polybrominated diphenyl ethers. 2017.
European Chemicals Bureau. European Union risk assessment report: Diphenyl ether, octabromo derivative. 2003.
Gill U, Chu I, Ryan JJ, Feeley M. Polybrominated Diphenyl Ethers: Human Tissue Levels and Toxicology. In: Ware GW, editor. Reviews of Environmental Contamination and Toxicology [Internet]. New York, NY: Springer New York; 2004 [cited 2023 Dec 29]. p. 55-97. (Reviews of Environmental Contamination and Toxicology; vol. 183). Available from: http://link.springer.com/10.1007/978-1-4419-9100-3_3
EPA. Polybrominated diphenyl ethers (PBDEs) action plan. In United States Environmental Protection Agency. 2009.
Gorini F, Iervasi G, Coi A, Pitto L, Bianchi F. The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives. Int J Environ Res Public Health. 2018 Aug 24;15(9):1834.
Venier M, Salamova A, Hites RA. Halogenated Flame Retardants in the Great Lakes Environment. Acc Chem Res. 2015 Jul 21;48(7):1853-61.
Hammel SC, Hoffman K, Lorenzo AM, Chen A, Phillips AL, Butt CM, et al. Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels. Environ Int. 2017 Oct;107:181-9.
Ekpe OD, Choo G, Barceló D, Oh JE. Introduction of emerging halogenated flame retardants in the environment. In: Comprehensive Analytical Chemistry [Internet]. Elsevier; 2020 [cited 2023 Dec 29]. p. 1-39. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0166526X19301060
Hooper K, McDonald TA. The PBDEs: an emerging environmental challenge and another reason for breast-milk monitoring programs. Environ Health Perspect. 2000 May;108(5):387-92.
Abbasi G, Li L, Breivik K. Global Historical Stocks and Emissions of PBDEs. Environ Sci Technol. 2019 Jun 4;53(11):6330-40.
Li WL, Ma WL, Jia HL, Hong WJ, Moon HB, Nakata H, et al. Polybrominated Diphenyl Ethers (PBDEs) in Surface Soils across Five Asian Countries: Levels, Spatial Distribution, and Source Contribution. Environ Sci Technol. 2016 Dec 6;50(23):12779-88.
Maddela NR, Venkateswarlu K, Kakarla D, Megharaj M. Inevitable human exposure to emissions of polybrominated diphenyl ethers: A perspective on potential health risks. Environ Pollut. 2020 Nov;266:115240.
Bocio A, Llobet JM, Domingo JL, Corbella J, Teixidó A, Casas C. Polybrominated Diphenyl Ethers (PBDEs) in Foodstuffs: Human Exposure through the Diet. J Agric Food Chem. 2003 May 1;51(10):3191-5.
Wang HS, Jiang GM, Chen ZJ, Du J, Man YB, Giesy JP, et al. Concentrations and congener profiles of polybrominated diphenyl ethers (PBDEs) in blood plasma from Hong Kong: Implications for sources and exposure route. J Hazard Mater. 2013 Oct;261:253-9.
Ma X, Zhang H, Yao Z, Zhao X, Wang L, Wang Z, et al. Bioaccumulation and trophic transfer of polybrominated diphenyl ethers (PBDEs) in a marine food web from Liaodong Bay, North China. Mar Pollut Bull. 2013 Sep;74(1):110-5.
Bedi M, Von Goetz N, Ng C. Estimating polybrominated diphenyl ether (PBDE) exposure through seafood consumption in Switzerland using international food trade data. Environ Int. 2020 May;138:105652.
Shaw SD, Kannan K. Polybrominated Diphenyl Ethers in Marine Ecosystems of the American Continents: Foresight from Current Knowledge. Rev Environ Health [Internet]. 2009 Jan [cited 2023 Dec 29];24(3). Available from: https://www.degruyter.com/document/doi/10.1515/REVEH.2009.24.3.157/html
Hu G cheng, Dai J yin, Xu Z cheng, Luo X jun, Cao H, Wang J she, et al. Bioaccumulation behavior of polybrominated diphenyl ethers (PBDEs) in the freshwater food chain of Baiyangdian Lake, North China. Environ Int. 2010 May;36(4):309-15.
Genuis SK, Birkholz D, Genuis SJ. Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study. BioMed Res Int. 2017;2017:1-14.
Jiang Y, Yuan L, Lin Q, Ma S, Yu Y. Polybrominated diphenyl ethers in the environment and human external and internal exposure in China: A review. Sci Total Environ. 2019 Dec;696:133902.
Wu Z, He C, Han W, Song J, Li H, Zhang Y, et al. Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: A review. Environ Res. 2020 Aug;187:109531.
Hurley S, Goldberg D, Park JS, Petreas M, Bernstein L, Anton-Culver H, et al. A breast cancer case-control study of polybrominated diphenyl ether (PBDE) serum levels among California women. Environ Int. 2019 Jun;127:412-9.
Linares V, Bellés M, Domingo JL. Human exposure to PBDE and critical evaluation of health hazards. Arch Toxicol. 2015 Mar;89(3):335-56.
Leonetti C, Butt CM, Hoffman K, Miranda ML, Stapleton HM. Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues. Environ Int. 2016 Mar;88:23-9.
Li M, Liu Z, Gu L, Yin R, Li H, Zhang X, et al. Toxic effects of decabromodiphenyl ether (BDE-209) on human embryonic kidney cells. Front Genet [Internet]. 2014 May 6 [cited 2023 Dec 29];5. Available from: http://journal.frontiersin.org/article/10.3389/fgene.2014.00118/abstract
Wei Z, Xi J, Gao S, You X, Li N, Cao Y, et al. Metabolomics coupled with pathway analysis characterizes metabolic changes in response to BDE-3 induced reproductive toxicity in mice. Sci Rep. 2018;
Noyes PD, Stapleton HM. PBDE flame retardants: Toxicokinetics and thyroid hormone endocrine disruption in fish. Endocr Disruptors. 2014 Jan;2(1):e29430.
Zhang Z, Li S, Liu L, Wang L, Xiao X, Sun Z, et al. Environmental exposure to BDE47 is associated with increased diabetes prevalence: Evidence from community-based case-control studies and an animal experiment. Sci Rep. 2016 Jun 13;6(1):27854.
Zhang Z, Sun ZZ, Xiao X, Zhou S, Wang XC, Gu J, et al. Mechanism of BDE209-induced impaired glucose homeostasis based on gene microarray analysis of adult rat liver. Arch Toxicol. 2013 Aug;87(8):1557-67.
Kozlova EV, Chinthirla BD, Pérez PA, DiPatrizio NV, Argueta DA, Phillips AL, et al. Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring. Sci Rep. 2020 Oct 22;10(1):18102.
Wu L, Li Y, Ru H, Xie H, Yao F, Ni Z, et al. Parental exposure to 2,2?,4,4?5 - pentain polybrominated diphenyl ethers (BDE-99) causes thyroid disruption and developmental toxicity in zebrafish. Toxicol Appl Pharmacol. 2019 Jun;372:11-8.
Mhadhbi L, Fumega J, Boumaiza M, Beiras R. Acute toxicity of polybrominated diphenyl ethers (PBDEs) for turbot (Psetta maxima) early life stages (ELS). Environ Sci Pollut Res. 2012;
Zhang T, Zhou X, Xu A, Tian Y, Wang Y, Zhang Y, et al. Toxicity of polybrominated diphenyl ethers (PBDEs) on rodent male reproductive system: A systematic review and meta-analysis of randomized control studies. Sci Total Environ. 2020 Jun;720:137419.
Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, et al. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct;332:222-34.
Dunnick JK, Pandiri AR, Merrick BA, Kissling GE, Cunny H, Mutlu E, et al. Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice. Toxicol Rep. 2018;5:615-24.
Kodavanti PRS, Royland JE, Osorio C, Winnik WM, Ortiz P, Lei L, et al. Developmental Exposure to a Commercial PBDE Mixture: Effects on Protein Networks in the Cerebellum and Hippocampus of Rats. Environ Health Perspect. 2015 May;123(5):428-36.
Manuguerra S, Espinosa Ruiz C, Santulli A, Messina C. Sub-lethal Doses of Polybrominated Diphenyl Ethers, in Vitro, Promote Oxidative Stress and Modulate Molecular Markers Related to Cell Cycle, Antioxidant Balance and Cellular Energy Management. Int J Environ Res Public Health. 2019 Feb 18;16(4):588.
Bjurlid F, Dam M, Hoydal K, Hagberg J. Occurrence of polybrominated dibenzo-p-dioxins, dibenzofurans (PBDD/Fs) and polybrominated diphenyl ethers (PBDEs) in pilot whales (Globicephala melas) caught around the Faroe Islands. Chemosphere. 2018 Mar;195:11-20.
Hartinie Marbawi, Ahmad Razi Othman, Mohd Izuan Effendi, Halmi, Jualang Azlan Gansau and Nur Adeela Yasid, Muhammad Arif Mukhriz Ros Saidon Khudri. Kinetic Analysis of the Adsorption of Glyphosate onto Palm Oil Fronds Activated Carbon. Hibiscus Publ. 7(1):29033.
Chen X, Dong Y, Tian E, Xie L, Wang G, Li X, et al. 4-Bromodiphenyl ether delays pubertal Leydig cell development in rats. Chemosphere. 2018 Nov;211:986-97.
Cai M, Li Y, Li Y, Du K. Physiological and biochemical responses and microscopic structure changes of Populus tomentosa Carr seedlings to 4-BDE exposure. Environ Sci Pollut Res. 2015 Sep;22(18):14258-68.
Ran S, Du C, Du KJ. Effects of 4-bromodiphenyl ether on the adventitious root differentiation of tissue culture seedlings of Triarrhena sacchariflora. Bioremediation J. 2020 Oct 1;24(4):283-92.
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