Seroprevalence of Hepatitis B Virus (HBV) among Blood donors in Federal Medical Centre Nguru, Yobe State, Nigeria

Authors

  • Rose Lami Kolo Department of Biological Science, Faculty of Science, Federal University Gashua, Nguru-Gashua Road, PMB 1005, Gashua, Yobe State, Nigeria.
  • S.W. Kopdorah Department of Biochemistry, Faculty of Science, Federal University Gashua, Nguru-Gashua Road, PMB 1005, Gashua, Yobe State, Nigeria.
  • Sani Chiroma Department of Biological Science, Faculty of Science, Federal University Gashua, Nguru-Gashua Road, PMB 1005, Gashua, Yobe State, Nigeria.
  • Comfort Philip Japhet National Biotechnology Development Agency (NABDA), Lugbe, Abuja, P.M.B 5118, Wuse, Abuja, Nigeria.
  • Titus Obadiah Jos University Teaching Hospital (JUTH), Lamingo, P.M.B. 2076, Jos, Plateau State, Nigeria
  • I. Gurumtet Department of Biochemistry, Faculty of Science, Karl Kumm University, Vom, PMB 2072, Jos South, Plateau State, Nigeria.
  • Y. Denkok Department of Biochemistry, Faculty of Science, Federal University Gashua, P. M. B 1005 Gashua, Yobe State Nigeria.
  • N.R. Gotan Department of Microbiology, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, PMB 2012, Plateau State, Nigeria.
  • S.T. Tyohemba Department of Biological Sciences, Faculty of Science, Federal University Kashere, P.M.B. 0182, Gombe State, Nigeria.

DOI:

https://doi.org/10.54987/jebat.v6i2.985

Keywords:

Hepatitis B, Blood donors, Seroprevalence, HBsAg screening, Awareness campaigns

Abstract

The hepatitis B virus is responsible for a highly contagious infectious disease that is transmitted through contact with infected blood or body fluids to non-immune persons, transfusion of blood containing infections, engaging in close, intimate sexual interactions, sharing of contaminated sharp objects, close personal contact in overcrowded environments, and via the placenta of an infected mother to an unborn child. This work aims to determine the seroprevalence of hepatitis B virus among blood donors in Federal Medical Centre Nguru, Yobe State, Nigeria. The screening of HBsAg was carried out using the BioApex one Step HBsAg test kit manufactured by Richmond Hill, Ontario, Canada. Nine (9) out of one hundred persons screened for HBsAg tested positive, giving a seroprevalence of 9.0%. Seroprevalence was significantly higher in donors of the age group 35–44 years old compared to donors of other age groups. The highest prevalence of 11.1% was recorded in donors with tertiary education. Fifty-three percent (53%) of the sample population did not have any knowledge about HBV prior to this study and had the highest prevalence of 6(11.3%) with P<0.05. The highest prevalence of 7(9.9%) was recorded in those with no family history of hepatitis compared with those with a family history. Donors with no history of blood transfusion and those who were not sure of being vaccinated had the highest prevalence of 9.6% and 25.0%, respectively. The seroprevalence of hepatitis B among blood donors in this study population was high. Awareness campaigns on its modes of transmission and prevention should be promoted and strengthened.

References

Dienstag JL, Isselbacher KJ. Acute viral hepatitis. In: Hawison S, editor. Principles of Internal Medicine. 6th ed. New York: McGraw-Hill Companies Inc.; 2005. p. 1822-38.

Brooks GF, Carroll KC, Butel JS, Morse SA. Medical Microbiology. International edition. New York: McGraw Hill Publishers; 2007. p. 425-43.

Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013. Lancet. 2015;386(10003):1546-55. doi:10.1016/S0140-6736(15)61412-X.

Samal J, Kandpal M, Vivekanandan P. Molecular mechanisms underlying occult hepatitis B virus infection. Clin Microbiol Rev. 2012;25(1):142-63. doi:10.1128/CMR.00018-11.

Hwang EW, Cheung R. Global epidemiology of hepatitis B virus infection. N Am J Med Sci. 2011;4:7-13.

Perz JF, Armstrong GL, Farrington LA. The contribution of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol. 2006;45:529-39.

Sirisena ND, Njoku MO, Idoko JA, Isamade E, Barau C, Jelpe D, et al. Carriage rate of hepatitis-B surface antigen (HbsAG) in an urban community in Jos, Plateau State, Nigeria. Niger Postgrad Med J. 2002;9:7-10.

Mohammed Y, Bekele A. Seroprevalence of transfusion-transmitted infection among blood donors at Jijiga blood bank, Eastern Ethiopia: retrospective 4 years study. BMC Res Notes. 2016;9(1):129. doi:10.1186/s13104-016-1925-6.

Zaheer HA, Waheed U. Blood safety system reforms in Pakistan. Blood Transfus. 2014;12(4):452-7.

Walana W, Ahiaba S, Hokey P, Vicar EK, Acquah SEK, Der EM. Seroprevalence of HIV, HBV and HCV among blood donors in Kintampo municipal hospitals, Ghana. Br Microbiol Res J. 2014;4(12):1491-9.

Bartonjo G, Oundo J, Ng'ang'a Z. Prevalence and factors associated with transfusion transmissible infections among blood donors at Regional Blood Transfusion Center Nakuru and Tenwek Mission Hospital. Pan Afr Med J. 2019;34:31.

Uneke CJ, Ogbu O, Inyama PU, Anyanwu GI, Njoku MO. Prevalence of hepatitis B virus among blood donors and human immunodeficiency virus infected patients in Jos, Nigeria. Mem Inst Oswaldo Cruz. 2005;100(1):13-6.

Ezeonu CM, Garba SA, Adabara NU, Kuta FA. Prevalence of hepatitis B virus infections among blood donors in Federal Capital Territory, Abuja, Nigeria. Afr J Clin Exp Microbiol. 2019;20(3):182-94.

Ugwuja EI. Seroprevalence of hepatitis B surface antigen and liver function test among adolescents in Abakiliki, South Eastern Nigeria. Int J Trop Med. 2010;6:1-6.

Damulak OD, Ogbenna V, Ma'an O, Rufai SD, Kut T, Bodund A. Hepatitis B virus sero-positivity among voluntary blood donors at a centralized blood service centre in Nigeria. Int J Med Appl Sci. 2013;2(3):10-8.

Altiparmak E, Olajumoke OO, Owolabi AD, Titilope AA, Adewumi A. Seroprevalence of hepatitis B e antigen (HBe antigen) and B core antibodies (IgG anti-HBcore and IgM anti-HBcore) among hepatitis B surface antigen positive blood donors at a tertiary centre in Nigeria. BMC Res Notes. 2012;5:167.

Agbesor NI, Amala SE, Zaccheaus AJ. Hepatitis B Virus profile among blood donors in Federal Capital Territory Abuja, Nigeria. Int J Sci Res. 2016;5(7):1668-72. doi:10.21275/v5i7.NOV163915.

Aernan PT, Sar PT, Torkula SH. Prevalence of Plasmodia and Hepatitis B Virus co-infection in blood donors at Bishop Murray Medical Centre Makurdi, Benue State, Nigeria. Asian Pac J Trop Med. 2011;4(3):224-6.

Edia-Asuke UA, Abubakar Z, Asuke S. Seroprevalence of Hepatitis B infection among outpatients attending a public tertiary hospital in Kaduna State, Nigeria. Trop Med Surg. 2015;3:189. doi:10.4172/2329-9088.1000189.

World Health Organization (WHO). Viral hepatitis. Bull World Health Organ. 1998;76(5):643-808.

Nguyen TT, McPhee SJ, Stewart S, Gildengorin G, Zhang L, Wong C. Factors associated with hepatitis B testing among Vietnamese Americans. J Gen Intern Med. 2010;25:694-700.

National Program on Immunization. National Program on Immunization and Partners, Five Years National Strategic Plan 2003-2007. Abuja, Nigeria: NPI; 2002.

Mutimer DJ, Olomu A, Skidmore S, Olomu N, Ratcliffe D, Rodgers B, et al. Viral Hepatitis in Nigerian Sickle Cell disease and commercial blood donors. Q J Med. 1994;87:407-11.

Ali SA, Donahue RMJ, Qureshi H, Vermund SH. Hepatitis B and Hepatitis C in Pakistan: prevalence and risk factors. Int J Infect Dis. 2009;13(1):9-19.

Sarwar J, Ahmad W, Saleem M, Jamshed F, Gul N. Frequency of hepatitis B in asymptomatic patients of District Headquarters Hospital Kotli, Azad Kashmir. J Ayub Med Coll Abbottabad. 2010;22(4):139-42.

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Published

2023-12-31

How to Cite

Kolo, R. L. ., Kopdorah, S. ., Chiroma, S. ., Japhet, C. P. ., Obadiah, T. ., Gurumtet, I. ., Denkok, Y., Gotan, N., & Tyohemba, S. . (2023). Seroprevalence of Hepatitis B Virus (HBV) among Blood donors in Federal Medical Centre Nguru, Yobe State, Nigeria. Journal of Environmental Bioremediation and Toxicology, 6(2), 51–54. https://doi.org/10.54987/jebat.v6i2.985

Issue

Vol. 6 No. 2 (2023)

Section

Articles

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