Phytochemical Screening and Antiproliferative Potential of Some Medicinal Plants in Northeastern Nigeria

Authors

  • Jalil Idi James Biochemistry Department, Faculty of Science, Gombe State University, P.M.B 127, Tudun Wada, Gombe, Nigeria.
  • Khalid Ibrahim Madugu Biochemistry Department, Faculty of Science, Gombe State University, P.M.B 127, Tudun Wada, Gombe, Nigeria.
  • Furaira Isa Sulaiman Biochemistry Department, Faculty of Science, Gombe State University, P.M.B 127, Tudun Wada, Gombe, Nigeria.
  • Nabila Yusuf Yarima Biochemistry Department, Faculty of Science, Gombe State University, P.M.B 127, Tudun Wada, Gombe, Nigeria.
  • Abubakar Ahmad Biochemistry Department, Faculty of Science, Gombe State University, P.M.B 127, Tudun Wada, Gombe, Nigeria.
  • Abubakar Usman Abare Biochemistry Department, Faculty of Science, Gombe State University, P.M.B 127, Tudun Wada, Gombe, Nigeria.
  • Abubakar Abdullahi Biochemistry Department, Faculty of Science, Gombe State University, P.M.B 127, Tudun Wada, Gombe, Nigeria.
  • Salihu Abdussalam Biochemistry Department, Faculty of Science, Gombe State University, P.M.B. 027 Gombe, Nigeria.

DOI:

https://doi.org/10.54987/jebat.v6i1.814

Keywords:

Antiproliferative, Phytoconstituents, Sorghum bicolor seed, Inhibition, Anticancer

Abstract

The use of medicinal plants for the therapy of different disease conditions has been in practice for decades, this has been attributed to the various phytoconstituents present in plants.  This study seeks to investigate the presence of secondary metabolites and assess the growth inhibitory properties of the plant extracts Curcuma longa, Momordica balsamia, Prosopis africana, Zizipus mauritianai, Boswellia dalziel, Guiera senegalensis and Diospyros mespiliformis. The method used to assess the growth inhibitory potential of the extracts involved the incubation of viable Sorghum bicolor seed in different concentrations of the extracts and water as a control. The seeds radicle lengths were measured at different time intervals to ascertain the antiproliferative activity of the extracts. The results showed the presence of alkaloids, coumarins, flavonoids, phenolics, steroids, terpenoids, tannins, saponins, quinone, anthraquinone and glycosides. The antiproliferative potential of the plants was evident by the concentration-dependent decrease in the growth of the seeds in the different extracts. This suggests that when explored further; extracts from the different plants might be used as potential antitumor and anticancer agents.

References

Jamal Elmezughi, Hafsat Shiru, Carol Clement, Ru angelic Edrada-Ebel, Veronique seidel and Alexander Gray. Bioactive natural compound from Prosopis africana and Abies nobili. J Appl Pharm Sci. 2013;3(03):040-043.

Javad Sharifi-Rad, Farzad Kobarfard, Athar Ata, Seyed Abdulmajid Ayatollahi, Nafiseh Khosravi Dehaghi, Arun Kumar Jugran. Prosopis plant chemical composition and pharmacological attributes: Targeting clinical studies from preclinical evidence. Biomolecules. 2019;9(777); doi:10.3390/biom9120777.

Ibrahim, M. Mohammad, AA, Faisal, H. Musa. Biochemical and antimicrobial activity of Prosopis africana. Int J Environ Prob. 2018;4(1):19-23.

Sahdeo P. and Bharat B. A. Tumeric, the Golden Spice. Herbal Medicine: Biomolecular and Clinical Aspects, 2011; 2nd edition.

Lydia O. Ayanwuyi, Abdullahi H. Yaro & Olajumoke M. Abodunde . Analgesic and anti-inflammatory effects of the methanol stem bark extract of Prosopis africana, Pharm Biol. 2010;48(3):296-299, DOI: 10.3109/13880200903121006.

Ratnam KV, Bhakshu LM. Traditional Uses and Pharmacology of Boswellia Species. Frankincense-Gum Olibanum: Botany, oleoresin, chemistry, etraction, utilization, propagation, biotechnology, and conversation. 2023 Jul 17, Apple Academic Press. New York.

Thakur GS, Bag M, Sanodiya BS, Bhadouriya P, Debnath M, Prasad GB, Bisen PS. Momordica balsamina: a medicinal and neutraceutical plant for health care management. Curr Pharm Biotechnol. 2009;10(7):667-682.

Kaur I, Puri M, Ahmed Z, Blanchet FP, Mangeat B, Piguet V. Inhibition of HIV-1 replication by balsimin, a ribosome inactivating protein of Mormodica balsamina. PLos one. 2013;8(9):e73780.

Mshelia SH, Kurami Y. Anti-ulcerogenic effect of extracts of Momordica balsamina Linn against experimentally induced gastric ulceration in rats. Int J Med Plants Res. 2017;6(4):332-6.

Sule MS, Mohammed SY. Toxicological studies on the leaves of Guiera senegalensis and Psidium guajava in rats. Biol Environ Sci J Trop. 2006;3:81-3.

Ayinde BA, Agbakwuru U. Cytotoxic and growth inhibitory effects of the methanol extract Struchium sparganophora Ktze (Asteraceae) leaves. Pharmacogn Mag. 2010;6:293-7.

McLaughlin JL, Chang C, Smith DI. Bench-top bioassays for the discovery of bioactive natural products: An update. In: Atta-ur-Rahman, editor. Studies in Natural Products Chemistry. Vol 9. Amsterdam: Elsevier Science Publishers; 1991. pp. 383-409.

Sogbaike DA, Ogundaini AO, Adesanya SA. The effects of some synthesized stilbene analogues on Artemia salina naupalii and germination of Sorghum bicolor seeds. Niger J Nat Prod Med. 2002;6:19-25

Obuotor EM, Onajobi FD. Preliminary evaluation of cytotoxic properties of Raphia hookeri fruit mesocarp. Fitoterapia. 2000;71:190-2.

Ayinde BA, Omogbai EK, Ikpefan EO. Comparative cytotoxic and antiproliferative effects of Persea americana mill (lauraceae) leaf, stem and root barks. Niger J Pharm Sci. 2011;10:16-26.

Ajuru MG, Williams LF, Ajuru G. Qualitative and quantitative phytochemical screening of some plants used in ethnomedicine in the Niger Delta region of Nigeria. J Food Nutr Sci. 2017;5(5):198-205.

Madziga HA, Sanni S, Sandabe UK. Phytochemical and elemental analysis of Acalypha wilkesiana leaf. J Am Sci. 2010;6(11):510-4.

Otukesh H, Ghazanfari B, Fereshtehnejad SM, Bakhshayesh M, Hashemi M, Hoseini R, Chalian M, Salami A, Mehdipor L, Rahiminia A. NPHS2 mutations in children with steroid-resistant nephrotic syndrome. Iran J Kidney Dis. 2009;3(2):99-102.

Panda S, Kar A. Antidiabetic and antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin?3?O?glucoside. Biofactors. 2007

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Published

2023-07-31

How to Cite

James, J. I., Madugu, K. I., Sulaiman, F. I. ., Yarima, N. Y. ., Ahmad, A., Abare, A. U., Abdullahi, A. ., & Abdussalam, S. (2023). Phytochemical Screening and Antiproliferative Potential of Some Medicinal Plants in Northeastern Nigeria. Journal of Environmental Bioremediation and Toxicology, 6(1), 44–48. https://doi.org/10.54987/jebat.v6i1.814

Issue

Vol. 6 No. 1 (2023)

Section

Articles

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