Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs)-Producing Klebsiella pneumoniae in Malaysian Clinical and Community Infections: A Systematic Review and Meta-Analysis

Authors

  • Salawudeen Adamu Department of Microbiology, Faculty of Science, Gombe State University, PMB 127, Tudun Wada Gombe, 760001 Gombe State, Nigeria.
  • Mohd Nasir Mohd Desa Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
  • Hui-Min Neoh UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia.
  • Siti Norbaya Masri Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
  • S.A. Ibrahim Department of Microbiology, Faculty of Science, Gombe State University, PMB 127, Tudun Wada Gombe, 760001 Gombe State, Nigeria.
  • L. Garba Department of Microbiology, Faculty of Science, Gombe State University, PMB 127, Tudun Wada Gombe, 760001 Gombe State, Nigeria.
  • A.J. Hadiza Department of Microbiology, Faculty of Science, Gombe State University, PMB 127, Tudun Wada Gombe, 760001 Gombe State, Nigeria.
  • A.M. Mubarak Department of Microbiology, Faculty of Science, Gombe State University, PMB 127, Tudun Wada Gombe, 760001 Gombe State, Nigeria.
  • Tengku Zetty Maztura Tengku Jamaluddin Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

DOI:

https://doi.org/10.54987/jebat.v7i2.1052

Keywords:

Prevalence, Extended Spectrum Beta Lactamases, Klebsiella pneumoniae, Malaysia, Clinical and Community Infections

Abstract

The increasing prevalence of extended-spectrum beta-lactamase-resistant (ESBL) Klebsiella pneumoniae in Malaysia is alarming. The lipopolysaccharide (LPS) of Klebsiella pneumoniae, particularly its lipid A moiety, plays a central role in the bacterium’s toxicological profile by inducing strong pro-inflammatory responses and contributing to septic shock in systemic infections. Morbidity and mortality associated with this condition are alarming. A comprehensive evaluation of the proportion of this phenomenon will aid the Malaysian government and health authorities in their efforts to reduce its burden. Hence, this systematic review and meta-analysis were conducted to evaluate the incidence of ESBL K. pneumoniae in Malaysian clinical and community infections. The study was conducted in accordance with the PRISMA guidelines and preceded by the development of an a priori protocol. The protocol was then registered in PROSPERO – the public registry for systematic reviews. Six important outcomes, including the assessment of the overall ESBL K. pneumoniae prevalence, were designed to be evaluated. A literature search was conducted in four selected electronic databases, and 310 articles were screened. Of these articles, only seven studies that met the eligibility criteria were included in the review. Relevant data were extracted from the included studies. By conducting a meta-analysis of quality effects, the pooled prevalence of ESBL K. pneumoniae in Malaysia was estimated at 72% (CI: 39-97). The review also identified ESBL gene types occurring mostly in infections. The high prevalence of ESBL K. pneumoniae in this study area is highly significant and of both public health and clinical relevance. Overall, the findings of this review will assist in the effective prevention and control of this threat in the study area.

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Published

2024-12-25

How to Cite

Adamu, S., Desa, M. N. M. ., Neoh, H.-M., Masri, S. N. ., Ibrahim, S., Garba, L., Hadiza, A., Mubarak, A., & Jamaluddin, T. Z. M. T. (2024). Prevalence of Extended-Spectrum Beta-Lactamases (ESBLs)-Producing Klebsiella pneumoniae in Malaysian Clinical and Community Infections: A Systematic Review and Meta-Analysis. Journal of Environmental Bioremediation and Toxicology, 7(2), 106–113. https://doi.org/10.54987/jebat.v7i2.1052

Issue

Vol. 7 No. 2 (2024)

Section

Articles

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